Hydrogen Bond‐Mediated Self‐Shielded Moisture‐Responsive Structural Color for Time‐Temperature Indicating

Abstract Effective monitoring of the time‐temperature history of biological reagents, chemical drugs, and perishable foods during cold chain storage is crucial for ensuring their quality and efficacy. Time‐temperature indicators (TTIs) are developed to assess the cumulative impact of time and temperature on product quality. However, current indicators face challenges related to complex wrapping procedures, narrow tracking ranges, susceptibility to photobleaching, and pre‐use instability, hampering widespread use. Herein, the first moisture‐responsive 1D photonic crystal (1DPC) TTIs featuring robust structural colors, customizable time‐temperature ranges, and reliable renewability are demonstrated. The indicators exhibit distinct color‐changing responsiveness toward water vapor, which remains observable after prolonged storage at low temperatures. Significantly, the moisture responsiveness gradually diminishes at elevated temperatures over time due to ambient water‐induced hydrogen bond formation, effectively shielding the indicator from external stimuli. This property enables the naked‐eye inspection of product efficacy during cold chain storage. Additionally, the endowed flexibility of the TTI facilitates its easy attachment to targets, functioning as a convenient indicator label. Remarkably, the indicator can be stably stored for an extended period at room temperature before use, thereby showcasing substantial market potential.