人类免疫缺陷病毒(HIV)
抗逆转录病毒疗法
医学
传输(电信)
病毒复制
重症监护医学
作为预防的治疗
免疫学
病毒学
病毒
病毒载量
计算机科学
电信
作者
Yusuke Matsui,Yasuo Miura
出处
期刊:Cells
[MDPI AG]
日期:2023-12-28
卷期号:13 (1): 64-64
被引量:3
标识
DOI:10.3390/cells13010064
摘要
The treatment of human immunodeficiency virus (HIV-1) has evolved since the establishment of combination antiretroviral therapy (ART) in the 1990s, providing HIV-infected individuals with approaches that suppress viral replication, prevent acquired immunodeficiency syndrome (AIDS) throughout their lifetime with continuous therapy, and halt HIV transmission. However, despite the success of these regimens, the global HIV epidemic persists, prompting a comprehensive exploration of potential strategies for an HIV cure. Here, we offer a consolidated overview of cell-based therapies for HIV-1, focusing on CAR-T cell approaches, gene editing, and immune modulation. Persistent challenges, including CAR-T cell susceptibility to HIV infection, stability, and viral reservoir control, underscore the need for continued research. This review synthesizes current knowledge, highlighting the potential of cellular therapies to address persistent challenges in the pursuit of an HIV cure.
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