生物
神经嵴
内皮素受体
内皮素1
信号转导
细胞生物学
体内
受体
神经科学
遗传学
胚胎
作者
Stanley M. Kanai,David E. Clouthier
出处
期刊:Development
[The Company of Biologists]
日期:2023-12-11
卷期号:150 (24)
被引量:1
摘要
Since the discovery of endothelin 1 (EDN1) in 1988, the role of endothelin ligands and their receptors in the regulation of blood pressure in normal and disease states has been extensively studied. However, endothelin signaling also plays crucial roles in the development of neural crest cell-derived tissues. Mechanisms of endothelin action during neural crest cell maturation have been deciphered using a variety of in vivo and in vitro approaches, with these studies elucidating the basis of human syndromes involving developmental differences resulting from altered endothelin signaling. In this Review, we describe the endothelin pathway and its functions during the development of neural crest-derived tissues. We also summarize how dysregulated endothelin signaling causes developmental differences and how this knowledge may lead to potential treatments for individuals with gene variants in the endothelin pathway.
科研通智能强力驱动
Strongly Powered by AbleSci AI