清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Long term clinical outcome of sirolimus drug coated balloons in large coronary vessels

医学 再狭窄 靶病变 西罗莫司 经皮冠状动脉介入治疗 冠状动脉 临床终点 支架 病变 心肌梗塞 心脏病学 外科 内科学 药物洗脱支架 动脉 放射科 临床试验
作者
Alessandro Sciahbasi,Nicolò Salvi,Tay Mok Heang,Ignacio Sánchez-Pérez,Salvatore Geraci,Giovanni Vaccaro,Susanna Benincasa,Amin Ariff Nuruddin,Raymundo Ocaranza,Francesco Giannini,Antonio Greco,Bernardo Cortese
出处
期刊:Catheterization and Cardiovascular Interventions [Wiley]
卷期号:103 (4): 532-538 被引量:1
标识
DOI:10.1002/ccd.30996
摘要

Abstract Background Studies evaluating the safety and efficacy of drug coating balloons (DCB) for the treatment of lesions in large coronary vessel are limited. Aims Our study aimed to evaluate the performance of a sirolimus DCB in large coronary arteries. Methods We analyzed all the procedures included in the EASTBOURNE Registry (NCT03085823) enrolling patients with a clinical indication to percutaneous coronary intervention performed by a sirolimus DCB according to investigator judgment. In the present analysis, a cut‐off of 2.75 mm was used to define large coronary arteries. Primary endpoint of the study was clinically driven target lesion revascularization (TLR) at 24 months whereas secondary endpoint included procedural success, myocardial infarction (MI), cardiac death and total mortality. Results Among the 2123 patients and 2440 lesions enrolled in the EASTBOURNE study between 2016 and 2020, 757 patients/810 lesions fulfilled the criteria for the present analysis. Mean reference vessel diameter was 3.2 ± 0.3 mm with mean lesion length of 22 ± 7 mm. Procedural success was high (96%) and at 2‐year follow up the device showed a good efficacy with a TLR rate of 9%. There were 34 deaths (4.5%), 30 MIs (4%) and 8 BARC type 3–5 bleedings (1.1%). In‐stent restenosis (629 lesions) and de novo lesions (181) were associated with 11% and 4% rates of TLR at 2 years, respectively ( p = 0.003). Conclusions Clinical performance of a sirolimus DCB in large coronary artery vessels shows promising signals at 2‐year follow up, both in de novo and in‐stent restenosis lesions.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
8秒前
14秒前
baobeikk完成签到,获得积分10
20秒前
量子星尘发布了新的文献求助10
25秒前
29秒前
无悔完成签到 ,获得积分10
54秒前
科研通AI2S应助科研通管家采纳,获得10
1分钟前
亿亿亿亿发布了新的文献求助10
1分钟前
拉长的秋白完成签到 ,获得积分10
1分钟前
1分钟前
1分钟前
1分钟前
顾矜应助满天都是大萌德采纳,获得10
1分钟前
xiaosui完成签到 ,获得积分10
1分钟前
学术laji完成签到 ,获得积分10
1分钟前
2分钟前
量子星尘发布了新的文献求助10
2分钟前
lixuebin完成签到 ,获得积分10
2分钟前
2分钟前
迷你的夜天完成签到 ,获得积分10
2分钟前
lyj完成签到 ,获得积分10
2分钟前
2分钟前
3分钟前
3分钟前
Emma应助冷静的小虾米采纳,获得200
3分钟前
3分钟前
Sunny完成签到,获得积分10
3分钟前
3分钟前
3分钟前
量子星尘发布了新的文献求助10
3分钟前
3分钟前
Ava应助精明晓刚采纳,获得10
3分钟前
NattyPoe完成签到,获得积分10
4分钟前
小西完成签到 ,获得积分10
4分钟前
4分钟前
蛋卷完成签到 ,获得积分10
4分钟前
烟花应助雪上一枝蒿采纳,获得10
4分钟前
4分钟前
5分钟前
科研通AI2S应助科研通管家采纳,获得30
5分钟前
高分求助中
The Mother of All Tableaux Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 2400
Ophthalmic Equipment Market by Devices(surgical: vitreorentinal,IOLs,OVDs,contact lens,RGP lens,backflush,diagnostic&monitoring:OCT,actorefractor,keratometer,tonometer,ophthalmoscpe,OVD), End User,Buying Criteria-Global Forecast to2029 2000
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind (Sixth Edition) 1000
Optimal Transport: A Comprehensive Introduction to Modeling, Analysis, Simulation, Applications 800
Official Methods of Analysis of AOAC INTERNATIONAL 600
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 588
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3960142
求助须知:如何正确求助?哪些是违规求助? 3506271
关于积分的说明 11128795
捐赠科研通 3238345
什么是DOI,文献DOI怎么找? 1789709
邀请新用户注册赠送积分活动 871870
科研通“疑难数据库(出版商)”最低求助积分说明 803069