Prognostic value of tertiary lymphoid structures (TLS) in digestive system cancers: a systematic review and meta-analysis

医学 危险系数 荟萃分析 内科学 外科肿瘤学 肿瘤科 总体生存率 癌症 子群分析 人口 比例危险模型 置信区间 环境卫生
作者
Hao Sun,Yuanyu Shi,Hailiang Ran,Junwei Peng,Qiongxian Li,Guiqing Zheng,Yandie He,Shuqing Liu,Wei Chang,Yuanyuan Xiao
出处
期刊:BMC Cancer [BioMed Central]
卷期号:23 (1) 被引量:8
标识
DOI:10.1186/s12885-023-11738-w
摘要

Abstract Background Existing literature suggests that tertiary lymphatic structure (TLS) is associated with the progression of cancer. However, the prognostic role of TLS in digestive system cancers remains controversial. This meta-analysis aims to synthesize currently available evidence in the association between TLS and the survival of digestive system cancers. Methods We systematically searched three digital databases (PubMed, Embase, Web of Science) for articles published from database inception to December 23, 2022. Study selection criteria are based on PECO framework: P (population: patients with digestive system cancers), E (exposure: presence of TLS), C (comparator: absence of TLS), O (outcome: overall survival, OS; recurrence-free survival, RFS; disease-free survival, DFS). The Quality in Prognostic Studies (QUIPS) tool was used to assess risk of bias for included studies. The study protocol was registered with PROSPERO (CRD42023416307). Results A total of 25 studies with 6910 patients were included into the final meta-analysis. Random-effects models revealed that the absence of TLS was associated with compromised OS, RFS, and DFS of digestive system cancers, with pooled hazard ratios (HRs) of 1.74 (95% CI: 1.50–2.03), 1.96 (95% CI: 1.58–2.44), and 1.81 (95% CI: 1.49–2.19), respectively. Subgroup analyses disclosed a stronger TLS-survival association for pancreatic cancer, compared with other digestive system cancers. Conclusion TLS may be of prognostic significance for digestive system cancers. More original studies are needed to further corroborate this finding.

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Lucas应助liuyue采纳,获得10
刚刚
刚刚
dew应助雪白炎彬采纳,获得100
1秒前
香蕉觅云应助www采纳,获得10
1秒前
积极鸵鸟完成签到,获得积分10
1秒前
研友_VZG7GZ应助mirutio采纳,获得10
1秒前
鹿立轩完成签到 ,获得积分10
2秒前
酷波er应助小何采纳,获得10
2秒前
kdjm688发布了新的文献求助10
2秒前
三金发布了新的文献求助10
3秒前
Angel发布了新的文献求助10
3秒前
Aaaalii发布了新的文献求助10
3秒前
3秒前
3秒前
3秒前
科研通AI6.3应助distinct采纳,获得10
4秒前
fcyyc发布了新的文献求助10
4秒前
Rui完成签到,获得积分20
5秒前
LIMO完成签到,获得积分10
5秒前
桐桐应助yuaasusanaann采纳,获得10
6秒前
bkagyin应助赖皮蛇采纳,获得10
6秒前
6秒前
6秒前
ding应助Dylan采纳,获得10
6秒前
脑洞疼应助quit123采纳,获得30
7秒前
慕青应助Ming采纳,获得10
7秒前
7秒前
Owen应助奋斗土豆采纳,获得10
7秒前
科目三应助陈不档采纳,获得10
8秒前
9秒前
9秒前
糊涂的新竹完成签到,获得积分10
9秒前
9秒前
JIE应助123采纳,获得10
9秒前
老实雨莲完成签到,获得积分10
9秒前
Jenny完成签到,获得积分10
9秒前
Akim应助三金采纳,获得10
10秒前
10秒前
丘比特应助Aaaalii采纳,获得10
10秒前
WATeam完成签到,获得积分0
10秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
Resistance Spot Welding Dataset for Automobile Body-in-White Quality Analysis 748
日本現代怪異事典 副読本 700
悉尼大学博士学位论文,题目:Modelling and testing of one-sided stitched laminated composites. 作者:Kristopher P. Plain 650
Machine Learning for Asset Management and Pricing 600
Numerical analysis of the coupled atmosphere-ocean models (CAO II). II 600
Models for the coupled atmosphere and ocean 600
热门求助领域 (近24小时)
化学 材料科学 医学 生物 纳米技术 工程类 有机化学 化学工程 生物化学 计算机科学 内科学 物理 复合材料 催化作用 细胞生物学 无机化学 光电子学 物理化学 电极 基因
热门帖子
关注 科研通微信公众号,转发送积分 7387941
求助须知:如何正确求助?哪些是违规求助? 8994426
关于积分的说明 19138212
捐赠科研通 7024605
什么是DOI,文献DOI怎么找? 3228214
关于科研通互助平台的介绍 2390785
邀请新用户注册赠送积分活动 2209310