废止
二氟卡宾
化学
氟利昂
组合化学
有机化学
催化作用
作者
Qiongjie Zhou,Mi Huang,Yi Shen,Zhenling Chen,Liying Xu,Zhigang Yang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2024-02-01
卷期号:26 (6): 1212-1217
标识
DOI:10.1021/acs.orglett.4c00011
摘要
As an inexpensive industrial chemical, chlorodifluoromethane (Freon-22), despite its relatively low reactivity, can serve as a practical CF2 source for the construction of gem-difluorinated ring structures. Here, we develop a protocol for the efficient assembly of valuable fluorinated 2,3-dihydrobenzofurans from the [4 + 1] annulation in good yields under basic conditions. The reliable practicability and scalability of the process have also been demonstrated by preparation at the multigram scale, late-stage modifications of pharmaceutical molecules, and potential antitumor potency.
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