Copper Mediated Direct Amination: Synthesis of 1,2,3,15 a‐tetrahydro‐14H‐pyrrolo[1,2‐a]quinazolino[3,2‐c]quinazolin‐14‐onederivatives via 2‐(2‐bromophenyl)quinazolin‐4(3H)‐ones

Abstract A convenient one pot method developed for synthesisof fused pyrroloquinazolinone and amino quinazolinone derivatives starting from 2‐bromo benzaldehyde, anthranilamide through in situ formation of2‐(2‐bromophenyl)quinazolin‐4(3 H )‐one and subsequent reaction withdifferent amino acids/cyclic secondary amines under aerobic conditions. The multicomponent protocol mediated by copper (II) salt involves direct amination with 2‐(2‐bromophenyl)quinazolin‐4(3 H )‐one, decarboxylation and cyclization to obtain polycyclic fused quinazolinone or aminated quinazolinone derivatives with the acceptable yields.