脱氧核酶
生物传感器
纳米技术
计算机科学
生化工程
材料科学
化学
工程类
生物化学
DNA
作者
Richa Pandey,Yang Lü,Erin M. McConnell,Enas Osman,Alexander P. Scott,Jimmy Gu,Todd Hoare,Leyla Soleymani,Yingfu Li
标识
DOI:10.1016/j.bios.2022.114983
摘要
DNAzyme-based electrochemical biosensors provide exceptional analytical sensitivity and high target recognition specificity for disease diagnosis. This review provides a critical perspective on the fundamental and applied impact of incorporating DNAzymes in the field of electrochemical biosensing. Specifically, we highlight recent advances in creating DNAzyme-based electrochemical biosensors for diagnosing infectious diseases, cancer and regulatory diseases. We also develop an understanding of challenges around translating the research in the field of DNAzyme-based electrochemical biosensors from labs to clinics, followed by a discussion on different strategies that can be applied to enhance the performance of the currently existing technologies to create truly point-of-care electrochemical DNAzyme biosensors.
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