Enantioselective hydromethylation of unfunctionalized olefins with copper-hydride catalysis

Recently in the Journal of the American Chemical Society , Buchwald and co-workers achieved enantioselective installation of a methyl group through copper-catalyzed hydromethylation. They demonstrated the utility of this method through the methylation of several olefin substrates, including drug molecules. Recently in the Journal of the American Chemical Society , Buchwald and co-workers achieved enantioselective installation of a methyl group through copper-catalyzed hydromethylation. They demonstrated the utility of this method through the methylation of several olefin substrates, including drug molecules.