Design and Synthesis of Urazole Derivatives via Ring Closing Metathesis

Abstract An efficient and short synthetic sequence to highly functionalized urazole derivatives is reported. N ‐substituted‐1,2,4‐triazoline‐3,5‐dione (TAD) is a versatile synthetic reagent. Here, simple reactions such as allylation, ring‐closing metathesis and hydrogenation were used successfully to construct the oxygenated urazole derivatives which may have implications in medicinal chemistry and organic synthesis.