体内
球茎
体外
荧光
合理设计
化学
分子
生物物理学
香豆素
材料科学
纳米技术
生物化学
生物
有机化学
物理
生物技术
量子力学
农学
作者
Han Zhao,Mei Wang,Zimeng Li,Yajing Meng,Zhenbo Guo,Pingzhu Zhang,Xiaoliu Li,Chao Wei
标识
DOI:10.1016/j.snb.2022.133059
摘要
Carbon monoxide (CO), a potential therapeutic gaseous molecule for the treatment of inflammation-related diseases, is difficult to deliver directly into the body. CO-releasing molecule (CORM)− 3 is an alternative molecule for in vivo delivery of CO. To track the distribution of CORM-3 in vitro and in vivo, we reasonably designed and synthesized a series of coumarin-pyridine dyads (1−3) by DFT calculation. Applying the 4-nitrobenzyl group as the recognition site, two new metal-free fluorescent probes (MFP-1/2) were used for CORM-3 detection. As expected, probe MFP-1/2 showed an obvious off-on fluorescent response after the reaction with CORM-3. Meanwhile, probe MFP-2 exhibited good selectivity and sensitivity to CORM-3 in PBS. With the aid of its large stock shift and red emitting wavelength, MFP-2 was successfully applied to track the distribution of CORM-3 in living cells and in mice.
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