Elevated Serum and Hair Levels of Cadmium as a Risk Factor for Liver Carcinoma: A Meta-Analysis

荟萃分析 医学 肝癌 肝细胞癌 子群分析 内科学 胃肠病学 癌症 出版偏见 风险因素 肿瘤科 化学 有机化学
作者
Zhiyong Liang,Yan Wang,Li Tian,Zhuo Wu,Yi Zhu
出处
期刊:Nutrition and Cancer [Routledge]
卷期号:75 (6): 1438-1447
标识
DOI:10.1080/01635581.2023.2192887
摘要

Background Cadmium (Cd) exposure might confer cancer risk. Published studies on the association between Cd levels and liver cancer risk have generated conflicting results. We aimed to conduct a meta-analysis to address the controversy.Methods Relevant literature was searched from the popular bio-databases up to Nov 2022. Essential information was extracted and data were pooled to assess the association between Cd levels and liver cancer risk. Subgroup analysis on sample types and geographical locations was conducted. Then, sensitivity analysis and bias diagnosis were performed to test the credibility of the results.Results Eleven publications comprising 14 independent studies were selected for analysis and the overall pooled data showed that Cd levels were markedly higher in liver cancer patients than those in healthy controls (SMD = 2.00; 95% CI = 1.20–2.81; P < 0.05). To get a prices estimation, the subgroup analyses showed that Cd levels in serum (SMD = 2.55; 95% CI = 1.65–3.45; P < 0.05) and hair (SMD = 2.08; 95% CI = 0.34–3.81; P < 0.05) were significantly higher in liver cancer patients than those in the healthy controls, respectively.Conclusions In summary, the data showed that Cd levels were markedly higher in liver cancer patients than those in healthy controls, indicating that Cd accumulation might play important role in the neoplastic transformation of liver cells.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
忆茶戏发布了新的文献求助10
刚刚
酷波er应助幸运星采纳,获得10
2秒前
华仔应助张雯思采纳,获得10
2秒前
CipherSage应助张雯思采纳,获得30
2秒前
星辰大海应助张雯思采纳,获得10
2秒前
搜集达人应助张雯思采纳,获得10
2秒前
2秒前
田様应助Cl1audia采纳,获得10
2秒前
123发布了新的文献求助10
3秒前
3秒前
搜集达人应助Ma采纳,获得10
3秒前
大模型应助孟欣玥采纳,获得10
3秒前
木可发布了新的文献求助10
4秒前
泊頔完成签到,获得积分10
6秒前
lrq发布了新的文献求助10
7秒前
7秒前
wwl关闭了wwl文献求助
9秒前
mr_chxb82发布了新的文献求助10
9秒前
阿智完成签到,获得积分10
9秒前
大写的LV完成签到 ,获得积分10
10秒前
麦子发布了新的文献求助10
11秒前
852应助wbh采纳,获得10
12秒前
16秒前
lzx发布了新的文献求助10
17秒前
王彩香发布了新的文献求助10
18秒前
五六七发布了新的文献求助150
19秒前
19秒前
mr_chxb82完成签到,获得积分10
19秒前
量子星尘发布了新的文献求助10
20秒前
小二郎应助麦子采纳,获得10
21秒前
清脆凡阳完成签到 ,获得积分10
21秒前
香蕉觅云应助小晓采纳,获得10
22秒前
科研通AI2S应助wwl采纳,获得10
24秒前
27秒前
眉间尺完成签到,获得积分10
29秒前
DC发布了新的文献求助10
30秒前
我们发布了新的文献求助10
32秒前
贪玩的野狍子完成签到,获得积分20
33秒前
、、、完成签到,获得积分10
38秒前
lrq完成签到,获得积分10
40秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989444
求助须知:如何正确求助?哪些是违规求助? 3531531
关于积分的说明 11254250
捐赠科研通 3270191
什么是DOI,文献DOI怎么找? 1804901
邀请新用户注册赠送积分活动 882105
科研通“疑难数据库(出版商)”最低求助积分说明 809174