声动力疗法
谷胱甘肽
癌症治疗
光动力疗法
活性氧
放射治疗
细胞内
癌症研究
癌症
癌细胞
癌症治疗
纳米医学
医学
药理学
化学
纳米技术
材料科学
生物化学
内科学
纳米颗粒
有机化学
酶
作者
Peng Liu,Hao Lu,Min Liu,Shuo Hu
标识
DOI:10.3389/fbioe.2023.1161472
摘要
Due to their rapid and uncontrolled proliferation, cancer cells are characterized by overexpression of glutathione (GSH), which impairs reactive oxygen species (ROS)-based therapy and weakens the chemotherapeutic agent-induced toxification. Extensive efforts have been made in the past few years to improve therapeutic outcomes by depleting intracellular GSH. Special focus has been given to the anticancer applications of varieties of metal nanomedicines with GSH responsiveness and exhaustion capacity. In this review, we introduce several GSH-responsive and -exhausting metal nanomedicines that can specifically ablate tumors based on the high concentration of intracellular GSH in cancer cells. These include inorganic nanomaterials, metal-organic frameworks (MOFs), and platinum-based nanomaterials. We then discuss in detail the metal nanomedicines that have been extensively applied in synergistic cancer therapy, including chemotherapy, photodynamic therapy (PDT), sonodynamic therapy (SDT), chemodynamic therapy (CDT), ferroptotic therapy, and radiotherapy. Finally, we present the horizons and challenges in the field for future development.
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