The International Consensus Classification of Acute Leukemias of Ambiguous Lineage

Letter to Blood| May 4, 2023 The International Consensus Classification of acute leukemias of ambiguous lineage Olga K. Weinberg, Olga K. Weinberg 1Department of Pathology, University of Texas Southwestern Medical Center Dallas, TX https://orcid.org/0000-0002-4250-3891 Search for other works by this author on: This Site PubMed Google Scholar Daniel A. Arber, Daniel A. Arber 2Department of Pathology, University of Chicago, Chicago, IL https://orcid.org/0000-0002-2160-9689 Search for other works by this author on: This Site PubMed Google Scholar Hartmut Döhner, Hartmut Döhner 3Department of Internal Medicine III, Ulm University Hospital, Ulm, Germany https://orcid.org/0000-0003-2116-5536 Search for other works by this author on: This Site PubMed Google Scholar Charles G. Mullighan, Charles G. Mullighan 4Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN https://orcid.org/0000-0002-1871-1850 Search for other works by this author on: This Site PubMed Google Scholar Etan Orgel, Etan Orgel 5Division of Hematology/Oncology, Children's Hospital Los Angeles, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA https://orcid.org/0000-0002-1487-6818 Search for other works by this author on: This Site PubMed Google Scholar Anna Porwit, Anna Porwit 6Division of Oncology and Pathology, Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden Search for other works by this author on: This Site PubMed Google Scholar Richard M. Stone, Richard M. Stone 7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA Search for other works by this author on: This Site PubMed Google Scholar Michael J. Borowitz Michael J. Borowitz 8Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD Search for other works by this author on: This Site PubMed Google Scholar Blood (2023) 141 (18): 2275–2277. https://doi.org/10.1182/blood.2022019493 Article history Submitted: December 21, 2022 Accepted: February 17, 2023 First Edition: March 6, 2023 Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Request Permissions Cite Icon Cite Search Site Citation Olga K. Weinberg, Daniel A. Arber, Hartmut Döhner, Charles G. Mullighan, Etan Orgel, Anna Porwit, Richard M. Stone, Michael J. Borowitz; The International Consensus Classification of acute leukemias of ambiguous lineage. Blood 2023; 141 (18): 2275–2277. doi: https://doi.org/10.1182/blood.2022019493 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBlood Search Subjects: Hematopoiesis and Stem Cells, Myeloid Neoplasia TO THE EDITOR: The International Consensus Classification of Myeloid and Lymphoid Neoplasms is the result of the findings of a clinical advisory committee (CAC) meeting with involvement by an international group of hematologists, oncologists, pathologists, and geneticists.1,2 The formal CAC meeting, however, did not address potential changes to the classification of acute leukemias of ambiguous lineage (ALAL); a CAC subgroup was created to address this issue (Table 1). ALAL include biologically diverse leukemias that fail to show commitment to either the myeloid or lymphoid lineages or show evidence of commitment to more than 1 lineage.1-3 Cases in the former group are referred to as acute undifferentiated leukemias (AUL), whereas those in the latter are identified as mixed-phenotype acute leukemias (MPAL). One of the major challenges in the subclassification of ALAL in general and MPAL in... References 1.Arber DA, Orazi A, Hasserjian RP, et al. International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data. Blood. 2022;140(11):1200-1228.Google ScholarCrossrefSearch ADS PubMed 2.Campo E, Jaffe ES, Cook JR, et al. The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee. Blood. 2022;140(11):1229-1253.Google ScholarCrossrefSearch ADS PubMed 3.Khoury JD, Solary E, Abla O, et al. 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Haematologica. 2021;106(8):2066-2075.Google ScholarCrossrefSearch ADS PubMed © 2023 by The American Society of Hematology2023 © 2023 by The American Society of Hematology2023 You do not currently have access to this content. Sign in via your Institution