边缘型人格障碍
氯胺酮
萧条(经济学)
精神科
医学
心情
重性抑郁障碍
临床心理学
难治性抑郁症
人格
心理学
精神分析
宏观经济学
经济
作者
Kevork Danayan,Noah Chisamore,Nelson B. Rodrigues,Joshua D. Di Vincenzo,Shakila Meshkat,Zoe Doyle,Rodrigo B. Mansur,Lee Phan,Farhan Fancy,Edmond Chau,Aniqa Tabassum,Kevin Kratiuk,Anil Arekapudi,Kayla M. Teopiz,Roger S. McIntyre,Joshua D. Rosenblat
标识
DOI:10.1016/j.psychres.2023.115133
摘要
Borderline personality disorder (BPD) has high rates of comorbidity with mood disorders, including treatment-resistant depression (TRD). Comorbidity of BPD with depression is associated with poorer response to antidepressants. Intravenous ketamine is a novel treatment for TRD that has not been specifically evaluated in patients with comorbid BPD. In this retrospective analysis of data collected from participants who received care at the Canadian Rapid Treatment Centre of Excellence (CRTCE; Braxia Health; ClinicalTrials.gov: NCT04209296), we evaluated the effectiveness of intravenous ketamine in a TRD population with comorbid BPD (N=100; n=50 BPD-positive compared with n=50 BPD-negative). Participants were administered four doses of intravenous ketamine (0.5-0.75mg/kg over 40 minutes) over two weeks. The primary outcome measures were changes in depressive symptom severity (as measured by Quick Inventory of Depressive Symptomatology–Self Report 16-item (QIDS-SR16)) and borderline symptom severity (as measured by Borderline Symptom List 23-item (BSL-23)). Both BPD-positive and BPD-negative groups improved significantly on the QIDS-SR16, QIDS-SR16 suicide ideation item, anxiety, and functionality scales with large effect sizes. There was no significant difference between groups. The BPD-positive group exhibited significant reduction of 0.64 on BSL-23 scores and a significant reduction of 5.95 on QIDS-SR16 scores. Patients with TRD and comorbid BPD receiving ketamine exhibited a significant reduction in symptoms of depression, borderline personality, suicidality, and anxiety.
科研通智能强力驱动
Strongly Powered by AbleSci AI