Cutaneous T-Cell Lymphoma: Current and Emerging Therapies

医学 蕈样真菌病 红皮病 淋巴瘤 皮肤T细胞淋巴瘤 皮肤病科 临床试验 伊布替尼 皮肤淋巴瘤 肿瘤科 内科学 慢性淋巴细胞白血病 白血病
作者
Kristie L. Kahl,Ryan McDonald,Hayley Assistant Managing,Ariana Pelosci,Russ Conroy,N. Wrigley,Jennifer Potash Vice,Angie Derosa,Nicole Canfora,Lupo Copy,Cheney Baltz,Marie-Louise Best,Kelly Senior,Georgina Substantive,Kirsty Mackay,Justin Mancini,Kim Nir,Ron Panarotti,Mercedes Pérez,Yasmeen Qahwash,Robert Mcgarr,Jonathan Severn Circulation,Brian Haug,Patric Pastore,Kristen Koederitz,Mike Hennessy,Ceo,Neil F. Glasser,Michael Ball,Brett Melillo,Terric Townsend,Joe Petroziello,Silas Inman,Shari Lundenberg,Phil Talamo,Jeff Brown,Julie Vose,M. Rizwan Rizwan-ul-Haq Khawaja,Marilyne Daher,Amy Spallone,Roy Chemaly,Omaha Ne,Howard Hochster,Breast Cancer,Sara Hurvitz,Los Angeles,Genitourinary Cancer,Robert A. Figlin,Gastrointestinal Cancer
出处
期刊:Oncology [MJH Life Sciences]
卷期号: (3702): 55-62 被引量:13
标识
DOI:10.46883/2023.25920984
摘要

Cutaneous T-cell lymphomas (CTCLs) are clinically heterogeneous T-cell lymphomas that arise in the skin and are characterized by their clinical and pathological features. This review will focus on mycosis fungoides (MF) and Sézary syndrome (SS), which represent 60% to 80% and less than 10% of CTCL cases, respectively. While most patients with MF present with patches and plaques and can be successfully treated with skin-directed therapies, a minority of patients progress from early to advanced stages or undergo large cell transformation. SS is defined as erythroderma, lymphadenopathy, and more than 1000 circulating atypical T-cells/uL with cerebriform nuclei. It has a poor overall survival of 2.5 years. Given the overall rarity of CTCLs, it is notable that clinical trials of treatments for MF/SS have been successfully completed, resulting in FDA approvals of novel therapies with increasing overall response rates. This review outlines the current multidisciplinary approach to diagnosing and treating MF/SS, with a focus on combining skin-directed therapies with emerging targeted and investigational systemic therapies. Integrating these anticancer therapies with skin care and bacterial decolonization is critical for comprehensive management. Curing patients with MF/SS may be possible by using a personalized medicine approach including novel combination strategies, restoration of T helper 1 cytokines, and avoidance of immunosuppressive regimens.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
yangjoy发布了新的文献求助10
1秒前
wanci应助老实的采蓝采纳,获得10
2秒前
威哥完成签到,获得积分10
3秒前
斯可发布了新的文献求助10
3秒前
桐桐应助lh961129采纳,获得10
4秒前
JUZI发布了新的文献求助10
5秒前
Lendar完成签到 ,获得积分10
5秒前
RuiBigHead发布了新的文献求助10
6秒前
7秒前
跳跃的洋葱完成签到 ,获得积分10
7秒前
7秒前
yangjoy完成签到,获得积分10
8秒前
pinklay完成签到 ,获得积分10
8秒前
8秒前
科研通AI5应助ttt采纳,获得10
9秒前
重要问旋完成签到,获得积分10
9秒前
10秒前
香蕉觅云应助科研通管家采纳,获得10
11秒前
11秒前
酷波er应助科研通管家采纳,获得10
11秒前
华仔应助科研通管家采纳,获得10
11秒前
wanci应助科研通管家采纳,获得30
11秒前
老阎应助科研通管家采纳,获得30
11秒前
姜莹应助科研通管家采纳,获得10
11秒前
隐形曼青应助科研通管家采纳,获得10
11秒前
顾矜应助科研通管家采纳,获得10
11秒前
共享精神应助科研通管家采纳,获得10
11秒前
大模型应助科研通管家采纳,获得10
11秒前
在水一方应助科研通管家采纳,获得10
11秒前
英姑应助科研通管家采纳,获得10
11秒前
CodeCraft应助科研通管家采纳,获得10
11秒前
11秒前
ED应助科研通管家采纳,获得10
12秒前
NexusExplorer应助科研通管家采纳,获得10
12秒前
12秒前
思源应助科研通管家采纳,获得10
12秒前
12秒前
orixero应助科研通管家采纳,获得10
12秒前
斯文败类应助科研通管家采纳,获得10
12秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038619
求助须知:如何正确求助?哪些是违规求助? 3576294
关于积分的说明 11375058
捐赠科研通 3306084
什么是DOI,文献DOI怎么找? 1819374
邀请新用户注册赠送积分活动 892698
科研通“疑难数据库(出版商)”最低求助积分说明 815066