葡萄糖氧化酶
过氧化氢
葡萄糖酸
光热治疗
光动力疗法
活性氧
材料科学
癌细胞
催化作用
肿瘤微环境
光热效应
化学
癌症
纳米技术
组合化学
癌症研究
肿瘤细胞
生物传感器
生物化学
有机化学
医学
内科学
作者
Mingjian Chen,Yuxin Yang,Le Tang,Shuyi He,Wanni Guo,Guili Ge,Zhaoyang Zeng,Xiaoling Li,Guiyuan Li,Wei Xiong,Xu Wu
标识
DOI:10.1002/adhm.202300839
摘要
Chemodynamic therapy (CDT) has emerged as an outstanding antitumor therapeutic method due to its selectivity and utilization of tumor microenvironment. However, there are still unmet requirements to achieve a high antitumor efficiency, including the tumor accumulation of catalyst and enrichment of reactants of Fenton reaction. Here, an iron-loaded semiconducting polymer dot modified with glucose oxidase (Pdot@Fe@GOx) is reported to deliver iron ions into tumor tissues and in situ generation of hydrogen peroxide in tumors. On one hand, Pdot@Fe@GOx converts glucose to gluconic acid and hydrogen peroxide (H2 O2 ) in tumor, which not only consumes glucose of tumor cells, but also provides the H2 O2 for the following Fenton reaction. On the other hand, the Pdot@Fe@GOx delivers active iron ions in tumor to perform CDT with the combination of the generated H2 O2 . In addition, the Pdot@Fe@GOx has both photothermal and photodynamic effects under the irradiation of near-infrared laser, which can improve and compensate the CDT effect to kill cancer cells. This Pdot@Fe@GOx-based multiple-mode therapeutic strategy has successfully achieved a synergistic anticancer effect with minimal side effects and has the potential to be translated into preclinical setting for tumor therapy.
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