列线图
医学
接收机工作特性
肝细胞癌
有效扩散系数
磁共振弥散成像
逻辑回归
单变量
单变量分析
核医学
曲线下面积
放射科
内科学
多元分析
多元统计
肿瘤科
磁共振成像
数学
统计
作者
Yunfei Zhang,Chun Yang,Ruofan Sheng,Yongming Dai,Mengsu Zeng
标识
DOI:10.1016/j.acra.2023.06.010
摘要
To noninvasively and preoperatively identify the microvascular invasion (MVI) of hepatocellular carcinoma (HCC) with the restricted spectrum imaging (RSI).62 patients were included into this prospective study and underwent the RSI examination with a 3.0-T scanner. Mono-exponential diffusion-weighted imaging-derived apparent diffusion coefficient (ADC) and RSI-derived metrics including f1 (fraction of restricted diffusion), f2 (fraction of hindered diffusion), f3 (fraction of free diffusion), and f1f2 (the multiply of f1 and f2) were calculated. Univariate and multivariate logistic regression were used to select the independent risk factors. Nomogram-based model was constructed with the selected indexes. Receiver operative characteristics analysis and calibration curve were used to evaluate the diagnostic accuracy.MVI-positive HCC showed significantly higher f1 and lower ADC values (ADC: 1.549 ± 0.228 ×10-3 vs 1.365 ± 0.239 ×10-3 mm2/s, P = .003; f1: 0.1633 ± 0.0341 vs 0.2221 ± 0.0491, P < .001). Tumor size and f1 were selected as independent risk factors for MVI. The nomogram-based model was then constructed with tumor size and f1. Nomogram-based model (area under ROC curve [AUC]= 0.856) yielded the best diagnostic accuracy followed by f1 (AUC=0.842) and ADC (AUC=0.708). The AUC of both the f1 and nomogram model were significantly higher than that of ADC.RSI-derived metrics can be utilized to noninvasively and efficiently identify the MVI of HCC. Considering the importance of MVI as a significant prognostic factor for HCC, the utilization of RSI has the potential to assist in prognostic prediction and clinical management.
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