亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Brain-predicted age difference estimated using DeepBrainNet is significantly associated with pain and function—a multi-institutional and multiscanner study

慢性疼痛 医学 大脑结构与功能 脑形态计量学 神经病理学 脑功能 磁共振成像 神经影像学 物理医学与康复 心理学 物理疗法 内科学 神经科学 精神科 疾病 放射科
作者
Pedro A. Valdés-Hernández,Chavier Laffitte Nodarse,Alisa J. Johnson,Soamy Montesino-Goicolea,Vishnu Bashyam,Christos Davatzikos,Julio A. Peraza,James H. Cole,Zhiguang Huo,Roger B. Fillingim,Yenisel Cruz‐Almeida
出处
期刊:Pain [Lippincott Williams & Wilkins]
卷期号:164 (12): 2822-2838 被引量:4
标识
DOI:10.1097/j.pain.0000000000002984
摘要

Abstract Brain age predicted differences (brain-PAD: predicted brain age minus chronological age) have been reported to be significantly larger for individuals with chronic pain compared with those without. However, a debate remains after one article showed no significant differences. Using Gaussian Process Regression, an article provides evidence that these negative results might owe to the use of mixed samples by reporting a differential effect of chronic pain on brain-PAD across pain types. However, some remaining methodological issues regarding training sample size and sex-specific effects should be tackled before settling this controversy. Here, we explored differences in brain-PAD between musculoskeletal pain types and controls using a novel convolutional neural network for predicting brain-PADs, ie, DeepBrainNet. Based on a very large, multi-institutional, and heterogeneous training sample and requiring less magnetic resonance imaging preprocessing than other methods for brain age prediction, DeepBrainNet offers robust and reproducible brain-PADs, possibly highly sensitive to neuropathology. Controlling for scanner-related variability, we used a large sample (n = 660) with different scanners, ages (19-83 years), and musculoskeletal pain types (chronic low back [CBP] and osteoarthritis [OA] pain). Irrespective of sex, brain-PAD of OA pain participants was ∼3 to 4.7 years higher than that of CBP and controls, whereas brain-PAD did not significantly differ among controls and CBP. Moreover, brain-PAD was significantly related to multiple variables underlying the multidimensional pain experience. This comprehensive work adds evidence of pain type–specific effects of chronic pain on brain age. This could help in the clarification of the debate around possible relationships between brain aging mechanisms and pain.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
无花果应助Heng采纳,获得10
9秒前
14秒前
15秒前
水刃木完成签到,获得积分10
17秒前
wzz完成签到,获得积分10
18秒前
20秒前
玩命的糖豆完成签到 ,获得积分10
27秒前
33秒前
38秒前
39秒前
星际舟完成签到,获得积分10
44秒前
冰渊悬月完成签到,获得积分10
46秒前
fsznc完成签到 ,获得积分0
46秒前
Dritsw应助ST采纳,获得10
47秒前
深情安青应助冰渊悬月采纳,获得10
54秒前
58秒前
不安的鸡翅完成签到,获得积分10
1分钟前
ZBQ发布了新的文献求助10
1分钟前
gezid完成签到 ,获得积分10
1分钟前
科研fw完成签到 ,获得积分10
1分钟前
jessie完成签到 ,获得积分10
1分钟前
coolkid应助zzz采纳,获得10
1分钟前
msk完成签到 ,获得积分10
1分钟前
zhiweiyan完成签到,获得积分10
1分钟前
1分钟前
YMS_DAMAOMI发布了新的文献求助10
1分钟前
1分钟前
ZBQ完成签到,获得积分10
1分钟前
善学以致用应助皮崇知采纳,获得10
1分钟前
1分钟前
CipherSage应助科研通管家采纳,获得10
1分钟前
爆米花应助科研通管家采纳,获得30
1分钟前
ymr完成签到 ,获得积分10
1分钟前
1分钟前
1分钟前
皮崇知发布了新的文献求助10
1分钟前
美满雁芙完成签到 ,获得积分10
1分钟前
彪壮的凡波完成签到,获得积分10
1分钟前
哦豁完成签到 ,获得积分10
1分钟前
比巴卜完成签到 ,获得积分10
2分钟前
高分求助中
Ophthalmic Equipment Market by Devices(surgical: vitreorentinal,IOLs,OVDs,contact lens,RGP lens,backflush,diagnostic&monitoring:OCT,actorefractor,keratometer,tonometer,ophthalmoscpe,OVD), End User,Buying Criteria-Global Forecast to2029 2000
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3965622
求助须知:如何正确求助?哪些是违规求助? 3510843
关于积分的说明 11155441
捐赠科研通 3245347
什么是DOI,文献DOI怎么找? 1792840
邀请新用户注册赠送积分活动 874118
科研通“疑难数据库(出版商)”最低求助积分说明 804188