转移RNA
癌变
翻译(生物学)
生物
癌症
机制(生物学)
遗传学
计算生物学
核糖核酸
基因
信使核糖核酸
哲学
认识论
作者
Daixi Ren,Yongzhen Mo,Mei Yang,Dan Wang,Yumin Wang,Qijia Yan,Can Guo,Wei Xiong,Fuyan Wang,Zhaoyang Zeng
出处
期刊:Cancer Letters
[Elsevier]
日期:2023-04-11
卷期号:563: 216170-216170
被引量:10
标识
DOI:10.1016/j.canlet.2023.216170
摘要
Transfer RNAs (tRNAs) play pivotal roles in the transmission of genetic information, and abnormality of tRNAs directly leads to translation disorders and causes diseases, including cancer. The complex modifications enable tRNA to execute its delicate biological function. Alteration of appropriate modifications may affect the stability of tRNA, impair its ability to carry amino acids, and disrupt the pairing between anticodons and codons. Studies confirmed that dysregulation of tRNA modifications plays an important role in carcinogenesis. Furthermore, when the stability of tRNA is impaired, tRNAs are cleaved into small tRNA fragments (tRFs) by specific RNases. Though tRFs have been found to play vital regulatory roles in tumorigenesis, its formation process is far from clear. Understanding improper tRNA modifications and abnormal formation of tRFs in cancer is conducive to uncovering the role of metabolic process of tRNA under pathological conditions, which may open up new avenues for cancer prevention and treatment.
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