炎症体
类风湿性关节炎
化学
体内
领域(数学分析)
效应器
关节炎
虚拟筛选
药物发现
受体
药理学
计算生物学
癌症研究
免疫学
生物化学
医学
生物技术
生物
数学
数学分析
作者
Bingyan Li,Pei Li,Liangming Wei,Jia Zou,Yuhang Wang,Qidong You,Cheng Jiang,Bin Di,Lili Xu
标识
DOI:10.1021/acs.jmedchem.3c02407
摘要
Rheumatoid arthritis (RA) is a chronic autoimmune disease. Targeting NLRP3 inflammasome, specifically its interaction with NEK7 via the LRR domain of NLRP3, is a promising therapeutic strategy. Our research aimed to disrupt this interaction by focusing on the LRR domain. Through virtual screening, we identified five compounds with potent anti-inflammatory effects and ideal LRR binding affinity. Lead compound
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