Total Mechano-synthesis of 2-Cyclopropyl-4-(4-Fluorophenyl) Quinoline-3-Acrylaldehyde—A Pivotal intermediate of Pitavastatin

A new three-step mechano-synthesis method starts with 4-bromoquinoline, uses Suzuki–Miyaura, Minisci C–H alkylation, and oxidation Heck coupling reactions, leading to rapid and eco-friendly synthesis of the key Pitavastatin intermediate.