J-Shaped Relationship Between Weight-Adjusted-Waist Index and Cardiovascular Disease Risk in Hypertensive Patients with Obstructive Sleep Apnea: A Cohort Study

医学 危险系数 队列 内科学 腰围 体质指数 阻塞性睡眠呼吸暂停 比例危险模型 置信区间 心脏病学 队列研究 睡眠呼吸暂停 肥胖
作者
Jianwen Zhao,Xintian Cai,Junli Hu,Shuaiwei Song,Qing Zhu,Di Shen,Wenbo Yang,Qin Luo,Xiaoguang Yao,Delian Zhang,Jing Hong,Nanfang Li
出处
期刊:Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy [Dove Medical Press]
卷期号:Volume 17: 2671-2681
标识
DOI:10.2147/dmso.s469376
摘要

Background: A newly introduced obesity-related index, the weight-adjusted-waist index (WWI), emerges as a promising predictor of cardiovascular disease (CVD).Given the known synergistic effects of hypertension and obstructive sleep apnea (OSA) on cardiovascular risk, we aimed to explore the relationship between the WWI and CVD risk specifically within this high-risk cohort.Methods: A total of 2265 participants with hypertension and OSA were included in the study.Multivariate Cox regression analysis was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for CVD events.The restricted cubic spline (RCS) was used to further evaluate the nonlinear dose-response relationship.Results: During a median follow-up period of 6.8 years, 324 participants experienced a CVD event.Multivariate Cox regression analysis revealed that compared to the reference group, the HRs for the second, third, and fourth groups were 1.12 (95% CI, 0.79-1.59),1.35 (95% CI, 0.96-1.89),and 1.58 (95% CI, 1.13-2.22),respectively.Moreover, RCS analysis illustrated a clear J-shaped relationship between the WWI and CVD risk, particularly notable when WWI exceeded 11.5 cm/ ffi ffi ffi ffi ffi kg p , signifying a significant increase in CVD risk.Conclusion: There was a J-shaped relationship between WWI and CVD in hypertensive patients with OSA, especially when the WWI was greater than 11.5 cm/ ffi ffi ffi ffi ffi kg p , the risk of CVD was significantly increased.
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