A novel pathogenic species of genus Stenotrophomonas: Stenotrophomonas pigmentata sp. nov

嗜麦芽窄食单胞菌 寡养单胞菌 生物 微生物学 假单胞菌 细菌 铜绿假单胞菌 遗传学
作者
Yue Li,Zelin Yu,Xueting Fan,Da Xu,Haican Liu,Xiuqin Zhao,Ruibai Wang
出处
期刊:Frontiers in Cellular and Infection Microbiology [Frontiers Media]
卷期号:14
标识
DOI:10.3389/fcimb.2024.1410385
摘要

Introduction Stenotrophomonas is a prominent genus owing to its dual nature. Species of this genus have many applications in industry and agriculture as plant growth-promoting rhizobacteria and microbial biological control agents, whereas species such as Stenotrophomonas maltophilia are considered one of the leading gram-negative multi-drug-resistant bacterial pathogens because of their high contribution to the increase in crude mortality and significant clinical challenge. Pathogenic Stenotrophomonas species and most clinical isolates belong to the Stenotrophomonas maltophilia complex (SMc). However, a strain highly homologous to S. terrae was isolated from a patient with pulmonary tuberculosis (TB), which aroused our interest, as S. terrae belongs to a relatively distant clade from SMc and there have been no human association reports. Methods The pathogenicity, immunological and biochemical characteristics of 610A2 T were systematically evaluated. Results 610A2 T is a new species of genus Stenotrophomonas , which is named as Stenotrophomonas pigmentata sp. nov. for its obvious brown water-soluble pigment. 610A2 T is pathogenic and caused significant weight loss, pulmonary congestion, and blood transmission in mice because it has multiple virulence factors, haemolysis, and strong biofilm formation abilities. In addition, the cytokine response induced by this strain was similar to that observed in patients with TB, and the strain was resistant to half of the anti-TB drugs. Conclusions The pathogenicity of 610A2 T may not be weaker than that of S. maltophilia . Its isolation extended the opportunistic pathogenic species to all 3 major clades of the genus Stenotrophomonas , indicating that the clinical importance of species of Stenotrophomonas other than S. maltophilia and potential risks to biological safety associated with the use of Stenotrophomonas require more attention.
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