Associations between exposure to phthalates and subclinical hypothyroidism in pregnant women during early pregnancy: A pilot case-control study in China

邻苯二甲酸盐 怀孕 医学 人口 内分泌学 亚临床感染 体质指数 甲状腺 内科学 优势比 生理学 生物 化学 环境卫生 遗传学 有机化学
作者
Zheng Yang,Danping Shan,Tao Zhang,Ludi Li,Shuo Wang,Ruihu Du,Yingzi Li,Shaowei Wu,Lei Jin,Yi Zhao,Xue‐Jun Shang,Qi Wang
出处
期刊:Environmental Pollution [Elsevier BV]
卷期号:320: 121051-121051 被引量:10
标识
DOI:10.1016/j.envpol.2023.121051
摘要

Phthalates are environmental endocrine disruptors with thyroid-disrupting properties; however, the association between phthalate exposure and subclinical hypothyroidism (SCH) during pregnancy is unknown. We recruited a study population from a cohort of pregnant women in Beijing, China, and conducted the present pilot case-control study of 42 SCH cases and 84 non-SCH controls matched with age and body mass index (BMI). Serum levels of thyroid peroxidase antibody, free thyroxine (FT4), thyroid-stimulating hormone (TSH), and urinary levels of ten phthalate metabolites during early pregnancy were measured. Urinary monoethyl phthalate (MEP) levels in SCH cases were observably higher than those in controls (p = 0.01). Conditional logistic regression analysis revealed that mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP), MEP, mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), and di-(2-ethylhexyl) phthalate (ΣDEHP) were significantly associated with a higher risk of SCH during early pregnancy (adjusted odds ratios = 1.89, 1.42, 1.81, and 1.92, respectively). Concomitantly, multiple linear regression analysis showed that MECPP, MEOHP, and ΣDEHP were positively associated with TSH and FT4 × TSH in the entire study population. Bayesian kernel machine regression analysis and stratified analysis by BMI revealed upward tendencies in the serum levels of TSH and FT4 × TSH. In summary, exposure to phthalates, especially DEHP, may be associated with a higher risk of SCH during early pregnancy, and a possible mechanism is the disruption of the hypothalamus-pituitary-thyroid axis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
完美世界应助忧心的不二采纳,获得10
1秒前
栉风沐雨发布了新的文献求助10
1秒前
11发布了新的文献求助10
2秒前
英俊的铭应助外向芹菜采纳,获得10
3秒前
wanci应助姚景涛采纳,获得10
4秒前
超级炎彬完成签到,获得积分10
5秒前
6秒前
6秒前
wangchaofk发布了新的文献求助20
7秒前
新新完成签到,获得积分10
8秒前
搜集达人应助小超超采纳,获得10
8秒前
付2完成签到,获得积分20
9秒前
55完成签到,获得积分20
9秒前
共享精神应助wangyup采纳,获得10
9秒前
小雨发布了新的文献求助10
10秒前
栉风沐雨完成签到,获得积分10
10秒前
11秒前
魔幻凝云发布了新的文献求助40
12秒前
posh完成签到 ,获得积分10
13秒前
13秒前
13秒前
15秒前
魔幻慕梅完成签到,获得积分10
15秒前
科研通AI2S应助结实的半双采纳,获得10
16秒前
16秒前
ionicliquids发布了新的文献求助10
16秒前
烂漫薯片完成签到,获得积分10
16秒前
SciGPT应助Passerby采纳,获得10
18秒前
上上谦完成签到,获得积分10
18秒前
18秒前
一裤子灰完成签到,获得积分10
19秒前
魔幻芒果发布了新的文献求助10
19秒前
19秒前
忧郁紫翠完成签到,获得积分20
20秒前
21秒前
芒果味猕猴桃完成签到,获得积分10
21秒前
柳叶小弯刀完成签到,获得积分10
22秒前
22秒前
wangchaofk完成签到,获得积分10
22秒前
圆圆发布了新的文献求助10
24秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3970048
求助须知:如何正确求助?哪些是违规求助? 3514739
关于积分的说明 11175783
捐赠科研通 3250115
什么是DOI,文献DOI怎么找? 1795198
邀请新用户注册赠送积分活动 875630
科研通“疑难数据库(出版商)”最低求助积分说明 804951