Preparation and characterization of injectable in-situ forming gel based on lipid liquid crystal for one month delivery of aripiprazole: In-vitro and in-vivo evaluations in rats

阿立哌唑 甘油 体内 化学 生物利用度 药物输送 色谱法 溶剂 药理学 有机化学 医学 精神分裂症(面向对象编程) 生物 生物技术 精神科
作者
Malihe Karimi,Shayan Azimi-Hashemi,Elham Khodaverdi,Marzieh Mohammadi,Farhad Eisvand,Adeleh Rahbardar-Khorasani,Rahim Nosrati,Hossein Kamali
出处
期刊:Journal of Drug Delivery Science and Technology [Elsevier BV]
卷期号:96: 105640-105640 被引量:5
标识
DOI:10.1016/j.jddst.2024.105640
摘要

The present study developed a one-month sustained-release formulation of aripiprazole, used for the treatment of schizophrenia and bipolar disorder, based on lipid liquid crystal (LLC) using phosphatidylcholine (PC) and N-methyl-2-pyrrolidone (NMP) solvent with sorbitan monooleate (SMO) or derivative glycerol oleate (glycerol monooleate (GMO), glycerol di-oleate (GDO), and glycerol trioleate (GTO)). The best formulation was selected based on the minimum initial burst release and the highest release of aripiprazole during the 30-day period. So, the formulations containing GMO and SMO exhibited the best initial slow release, while the other two formulations showed a burst release within 24 h. Furthermore, the GMO formulation did not release the drug completely during the 30-day study period, and the formulation containing GTO released the drug completely in less than a month. Therefore, the two formulations containing SMO and GDO were selected for further tests. The prepared liquid crystals had a hexagonal structure, indicating the creation of a suitable formulation structure with slow and controlled release. The area under the curve for the LLC-SMO formulation was higher than for other formulations, supporting the sustained release of aripiprazole and improving the long-term bioavailability of the drug. Moreover, this formulation was found to be safe and did not cause any damage to the skin at the injection site or vital organs such as the spleen, kidney, brain, heart, and liver. Hence, it can be considered a suitable option for developing an extended-release LLC formulation of aripiprazole.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
xmk完成签到 ,获得积分10
1秒前
cindywu完成签到,获得积分10
1秒前
ccc发布了新的文献求助10
1秒前
3秒前
4秒前
5秒前
5秒前
Star1983发布了新的文献求助10
9秒前
9秒前
坚定馒头发布了新的文献求助10
9秒前
项绝义发布了新的文献求助200
10秒前
Supreme发布了新的文献求助10
12秒前
13秒前
13秒前
15秒前
15秒前
15秒前
17秒前
青柠发布了新的文献求助10
17秒前
nannan发布了新的文献求助10
18秒前
19秒前
19秒前
19秒前
TKTK发布了新的文献求助30
19秒前
Stroeve发布了新的文献求助20
20秒前
24秒前
25秒前
26秒前
28秒前
lelelele发布了新的文献求助10
28秒前
29秒前
ZZZ发布了新的文献求助20
29秒前
爱科研发布了新的文献求助50
29秒前
Ava应助机灵的胡萝卜采纳,获得10
29秒前
258369发布了新的文献求助10
31秒前
cst发布了新的文献求助10
31秒前
钱宇成发布了新的文献求助10
31秒前
Ava应助美满的砖头采纳,获得10
33秒前
悄悄发布了新的文献求助10
33秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988868
求助须知:如何正确求助?哪些是违规求助? 3531255
关于积分的说明 11253071
捐赠科研通 3269858
什么是DOI,文献DOI怎么找? 1804822
邀请新用户注册赠送积分活动 881994
科研通“疑难数据库(出版商)”最低求助积分说明 809035