A novel composite of covalent organic framework and molecularly imprinted polymer with 1,1′-bis(allylcarbamoyl)ferrocene as cross-linker for ratiometric electrochemical detection of 5-hydroxytryptamine

共价键 二茂铁 连接器 分子印迹聚合物 电化学 复合数 聚合物 高分子化学 化学 材料科学 组合化学 有机化学 电极 选择性 催化作用 计算机科学 复合材料 物理化学 操作系统
作者
Mengna Hu,Yanbo Zeng,Rong Zhang,Yiwen Yang,Hailong Wang,Longhua Guo,Qiukai Tang,Lei Li
出处
期刊:Sensors and Actuators B-chemical [Elsevier BV]
卷期号:410: 135693-135693 被引量:5
标识
DOI:10.1016/j.snb.2024.135693
摘要

A novel covalent organic framework and molecularly imprinted polymer (COF-MIP) composite, incorporating 1,1'-bis(allylcarbamoyl)ferrocene (AC-Fc) as a cross-linker, was synthesized through free radical polymerization for the ratiometric electrochemical detection of 5-hydroxytryptamine (5-HT). The AC-Fc cross-linker was synthesized using 1,1'-ferrocenedicarboxylic acid as a reactant. Subsequently, the COF-MIP was prepared using surface imprinting technique, employing AC-Fc as the cross-linker, COF as the supporter, and 5-HT as the template. The COF-MIP was employed in the development of a ratiometric electrochemical sensor for 5-HT. Upon 5-HT introduction, the peak current of 5-HT exhibited a concentration-dependent increase, while that for ferrocene (Fc) remained nearly constant. By utilizing Fc and 5-HT peak currents as reference and indicator signals, respectively, 5-HT was quantitatively determined. The ratio of I5-HT/IFc for the COF-MIP sensor was 4.48, 3.57, and 1.98 times higher than those of non-imprinted polymer (NIP), traditional MIP, and COF-NIP sensors, respectively. The ratiometric sensor with COF-MIP demonstrated a linear ratiometric signal (I5-HT/IFc) in response to 5-HT concentrations within the range of 0.2-10 µM, with a detection limit of 0.03 µM. The relative standard deviation of the non-ratiometric and ratiometric sensors was 7.8% and 2.6%, respectively. This methodology was successfully employed for the detection of 5-HT in human serum.
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