Temporal interference stimulation targets deep primate brain

神经科学 刺激 脑深部刺激 立体脑电图 局部场电位 电场 脑电图 电生理学 灵长类动物 脑刺激 猕猴 干扰(通信) 计算机科学 生物医学工程 心理学 物理 医学 癫痫外科 病理 电信 频道(广播) 疾病 帕金森病 量子力学
作者
Ruobing Liu,Guanyu Zhu,Zhengping Wu,Yifei Gan,Jianguo Zhang,Jiali Liu,Liang Wang
出处
期刊:NeuroImage [Elsevier BV]
卷期号:291: 120581-120581 被引量:9
标识
DOI:10.1016/j.neuroimage.2024.120581
摘要

Temporal interference (TI) stimulation, a novel non-invasive stimulation strategy, has recently been shown to modulate neural activity in deep brain regions of living mice. Yet, it is uncertain if this method is applicable to larger brains and whether the electric field produced under traditional safety currents can penetrate deep regions as observed in mice. Despite recent model-based simulation studies offering positive evidence at both macro- and micro-scale levels, the absence of electrophysiological data from actual brains hinders comprehensive understanding and potential application of TI. This study aims to directly measure the spatiotemporal properties of the interfered electric field in the rhesus monkey brain and to validate the effects of TI on the human brain. Two monkeys were involved in the measurement, with implantation of several stereo-electroencephalography (SEEG) depth electrodes. TI stimulation was applied to anesthetized monkeys using two pairs of surface electrodes at differing stimulation parameters. Model-based simulations were also conducted and subsequently compared with actual recordings. Additionally, TI stimulation was administered to patients with motor disorders to validate its effects on motor symptoms. Through the integration of computational electric field simulation with empirical measurements, it was determined that the temporally interfering electric fields in the deep central regions are capable of attaining a magnitude sufficient to induce a subthreshold modulation effect on neural signals. Additionally, an improvement in movement disorders was observed as a result of TI stimulation. This study is the first to systematically measure the TI electric field in living non-human primates, offering empirical evidence that TI holds promise as a more focal and precise method for modulating neural activities in deep regions of a large brain. This advancement paves the way for future applications of TI in treating neuropsychiatric disorders.
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