Clinical Characteristics and Survival of Kidney Transplant Recipients with Posttransplant Malignancy

Objectives: Kidney transplant recipients are at increased risk of malignancy compared to the general population.The prognosis of posttransplant malignancy is poor, and data on how to manage immunosuppression are scarce.This study aimed to evaluate posttransplant malignancy incidence and its effects on graft and patient survival in kidney transplant recipients.Materials and Methods: Six hundred and twenty-eight patients who underwent kidney transplantation between 2000 and 2019 were retrospectively examined.Demographic data, transplant and cancer characteristics, graft and patient survival of 33 patients (5.26%) diagnosed posttransplant malignancy were evaluated. Results:The average age at malignancy diagnosis was 48 years.Malignancy distribution was as follows: solid organ tumors (57.6%), non-melanoma skin cancers (24.2%) and posttransplant lymphoproliferative disease (18.2%).The time from transplantation to malignancy diagnosis was 66 months.Immunosuppression was reduced in 45.5% of the patients and 54.5% had switched to mammalian target of rapamycin inhibitors.In posttransplant lymphoproliferative disease, all patients received chemotherapy and immunosuppression was reduced in 83.3%.These rates were significantly lower Öz Amaç: Böbrek nakli alıcıları, genel popülasyona kıyasla yüksek kanser riski altındadır.Nakil sonrası kanserin prognozu kötüdür ve immünosüpresyonun nasıl yönetileceğine dair veriler azdır.Bu çalışmada, merkezimizde takip edilen böbrek nakli alıcılarında kanser gelişimi insidansı ve kanser türlerinin greft ve hasta sağkalımına etkisinin değerlendirilmesi amaçlanmıştır.Gereç ve Yöntem: 2000 ve 2019 yılları arasında böbrek nakli yapılan 628 hasta retrospektif olarak incelenmiş ve nakil sonrası kanser tanısı alan 33 hastanın (%5,26) demografik verileri, nakil ve kanser özellikleri, greft ve hasta sağkalımları