Disulfidptosis decoded: a journey through cell death mysteries, regulatory networks, disease paradigms and future directions

程序性细胞死亡 疾病 神经科学 生物 细胞生物学 医学 细胞凋亡 病理 遗传学
作者
Jinyu Chen,Boyuan Ma,Yubiao Yang,B Wang,Jian Hao,Xianhu Zhou
出处
期刊:Biomarker research [Springer Nature]
卷期号:12 (1) 被引量:5
标识
DOI:10.1186/s40364-024-00593-x
摘要

Abstract Cell death is an important part of the life cycle, serving as a foundation for both the orderly development and the maintenance of physiological equilibrium within organisms. This process is fundamental, as it eliminates senescent, impaired, or aberrant cells while also promoting tissue regeneration and immunological responses. A novel paradigm of programmed cell death, known as disulfidptosis, has recently emerged in the scientific circle. Disulfidptosis is defined as the accumulation of cystine by cancer cells with high expression of the solute carrier family 7 member 11 (SLC7A11) during glucose starvation. This accumulation causes extensive disulfide linkages between F-actins, resulting in their contraction and subsequent detachment from the cellular membrane, triggering cellular death. The RAC1-WRC axis is involved in this phenomenon. Disulfidptosis sparked growing interest due to its potential applications in a variety of pathologies, particularly oncology, neurodegenerative disorders, and metabolic anomalies. Nonetheless, the complexities of its regulatory pathways remain elusive, and its precise molecular targets have yet to be definitively identified. This manuscript aims to meticulously dissect the historical evolution, molecular underpinnings, regulatory frameworks, and potential implications of disulfidptosis in various disease contexts, illuminating its promise as a groundbreaking therapeutic pathway and target.
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