Engineering Lauric Acid-based Nanodrug Delivery Systems for Restoring Chemosensitivity and Improving Biocompatibility of 5-FU & OxPt against Fn-Associated Colorectal Tumor

The tailored nanomedicine 5-FU-LA@PPL could selectively combat Fn , inhibit autophagy in CRC cells, restore chemosensitivity of 5-FU as well as OxPt, and consequently enhance the combination chemotherapy effects for Fn -associated drug-resistant CRC.