化学
亚硝酸盐还原酶
亚硝酸盐
硝酸还原酶
还原酶
硝酸盐
生物化学
酶
细胞色素
有机化学
作者
Krystina Hird,Julius Campeciño,Nicolai Lehnert,Eric L. Hegg
标识
DOI:10.1016/j.jinorgbio.2024.112542
摘要
Cytochrome c nitrite reductase, NrfA, is a soluble, periplasmic pentaheme cytochrome responsible for the reduction of nitrite to ammonium in the Dissimilatory Nitrate Reduction to Ammonium (DNRA) pathway, a vital reaction in the global nitrogen cycle. NrfA catalyzes this six-electron and eight-proton reduction of nitrite at a single active site with the help of its quinol oxidase partners. In this review, we summarize the latest progress in elucidating the reaction mechanism of ammonia production, including new findings about the active site architecture of NrfA, as well as recent results that elucidate electron transfer and storage in the pentaheme scaffold of this enzyme.
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