烯酮
克莱森重排
立体中心
化学
重排反应
重排
卡罗尔重排
立体化学
组合化学
药物化学
有机化学
对映选择合成
催化作用
出处
期刊:Tetrahedron
[Elsevier BV]
日期:2017-04-01
卷期号:73 (16): 2173-2190
被引量:4
标识
DOI:10.1016/j.tet.2017.03.004
摘要
From what began as a casual discovery of the ketene-Claisen rearrangement (the Malherbe-Belluš rearrangement) over 3 decades ago has flourished a reaction of substantial significance. The noticeable qualities of the ketene-Claisen rearrangement is accomplished in terms of experimental simplicity, forming new CC bonds, high levels of chemo- and stereocontrol, ring enlargements and constructing new stereocenters. This survey of the ketene-Claisen rearrangement with some applications in organic synthesis will not only recapitulate the prospective of this reaction so far but also illustrate the achievable future significant prospective.
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