医学
质子疗法
头颈部癌
背景(考古学)
放射治疗
医学物理学
质子
癌症
头颈部
核医学
内科学
放射科
外科
古生物学
物理
生物
量子力学
作者
Jonathan E. Leeman,Paul B. Romesser,Ying Zhou,Sean McBride,Nadeem Riaz,Eric Sherman,Marc A. Cohen,Oren Cahlon,Nancy Y. Lee
出处
期刊:Lancet Oncology
[Elsevier]
日期:2017-05-01
卷期号:18 (5): e254-e265
被引量:117
标识
DOI:10.1016/s1470-2045(17)30179-1
摘要
Use of proton beam therapy has expanded, with the number of proton centres rapidly increasing not only in the USA but also worldwide. The physical characteristics of the proton beam offer important advantages versus widely used photon techniques in terms of radiation precision. In head and neck cancer in particular, proton beam therapy is uniquely suited for the complex anatomy of tumours and sensitive surrounding organs. De-intensification and personalisation of treatment to limit toxicity are of renewed importance in the context of human papilloma virus-associated disease, in which young patients will be cured but bear the consequences of adverse effects for decades. Comparisons of radiation dose distributions between photon and proton techniques suggest considerable benefit in terms of toxicity sparing, but this has only recently been confirmed by substantial clinical data. In this Review, we attempt to define the role of this method in the contemporary multidisciplinary management of various types of head and neck cancer.
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