免疫衰老
免疫系统
炎症
肠道菌群
疾病
益生菌
免疫学
糖尿病
胰岛素抵抗
心理干预
微生物群
生物
医学
生物信息学
内科学
内分泌学
细菌
精神科
遗传学
作者
Alexander Vaiserman,Alexander Koliada,Francesco Marotta
标识
DOI:10.1016/j.arr.2017.01.001
摘要
Aging-associated alterations in composition, diversity and functional features of intestinal microbiota are well-described in the modern literature. They are suggested to be caused by an age-related decline in immune system functioning (immunosenescence) and a low-grade chronic inflammation (inflammaging), which accompany many aging-associated pathologies. The microbiota-targeted dietary and probiotic interventions have been shown to favorably affect the host health and aging by an enhancement of antioxidant activity, improving immune homeostasis, suppression of chronic inflammation, regulation of fat deposition and metabolism and prevention of insulin resistance. Recently, a high effectiveness and safety of novel therapeutic application such as fecal microbiota transplantation in the prevention and treatment of age-related pathological conditions including atherosclerosis, type 2 diabetes and Parkinson's disease has been demonstrated. In this review, recent research findings are summarized on the role of gut micribiota in aging processes with emphasis on therapeutic potential of microbiome-targeted interventions in anti-aging medicine.
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