Type I Interferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors

(Immunity 25, 349–360; September 2006) The original title of this paper misspelled “Interferon.” The correct title appears here, and Immunity regrets this error. Type I Inteferon Gene Induction by the Interferon Regulatory Factor Family of Transcription FactorsHonda et al.ImmunitySeptember, 2006In BriefInduction of type I interferons (IFNs) by viruses and other pathogens is crucial for innate immunity, and it is mediated by the activation of pattern-recognition receptors, such as Toll-like receptors and cytosolic receptors such as RIG-I and MDA5. The type I IFN induction is primarily controlled at the gene transcriptional level, wherein a family of transcription factors, interferon regulatory factors (IRFs), plays central roles. Here, we summarize the recent studies on IRFs, providing a paradigm of how genes are ingeniously regulated during immune responses. Full-Text PDF Open Archive