Comparison of Effect of Telmisartan and Weight Reduction on Histological Activity of Nonalcoholic Steatohepatitis: A One Year Randomised Control Trial

mon in the aged (>40 years) population. There are reports suggesting that older patients have more severe disease compared to younger population. The present study was aimed to compare the characteristics of old versus younger NAFLD patients. Materials and Methods: The anthropometric, biochemical and histological parameters of 270 old and 243 young NAFLD patients were compared. Results: The old NAFLD cases (mean age: 50.09 7.26) compared to younger patients (mean age: 33.48 4.8) had higher anthropometric indices (waist circumference: 97.64 10.79 vs. 94.4 7.87; P = 0.0007, waist–hip ratio: 0.98 0.07 vs. 0.95 0.05; P 0.05), fasting insulin (11.31 6.29 vs. 10.7 5.46; P = 0.41), triglyceride (204.33 143.17 vs. 201 110.53;P = 0.8),HDLCholesterol (42.94 17 vs. 44.16 15.93; P = 0.47), prevalence of metabolic syndrome (50.44% vs. 41.3%; P = 0.19) and histological activity [Definite NASH: 47% vs. 41%; P = 0.41, Hepatic Fibrosis: 36.47% vs. 25.26%; P = 0.1] were not statistically different between the old and young NAFLD patients. Conclusion: The older NAFLD patients did not have more severe disease, despite higher anthropometric indices and metabolic risk factors compared to younger patients.