肠道菌群
高尿酸血症
尿酸
生物
毛螺菌科
嘌呤
粪便
细菌
微生物学
厚壁菌
16S核糖体RNA
生物化学
酶
遗传学
作者
Xiu Liu,Qiulan Lv,Hongyan Ren,Liu Gao,Peng Zhao,Xiaomin Yang,Guanpin Yang,Daxing Xu,Guangtao Wang,Wan Yang,Pengjun Wang,Zenglan Wang,Shichao Xing
出处
期刊:PeerJ
[PeerJ]
日期:2020-03-06
卷期号:8: e8664-e8664
被引量:66
摘要
Some studies on the hyperuricemia (HUA) have focused on intestinal bacteria. To better understand the correlation between gut microbiota and HUA, we established a HUA rat model with high-purine diet, and used 16S rRNA genes sequencing to analyze gut microbiota changes in HUA rats. To analyze the potential role played by gut microbiota in HUA, we altered the gut microbiota of HUA rats with antibiotics, and compared the degree of uric acid elevation between HUA and antibiotic-fed HUA rats (Ab+HUA). Finally, we established a recipient rat model, in which we transplanted fecal microbiota of HUA and normal rats into recipient rats. Three weeks later, we compared the uric acid content of recipient rats. As a result, the diversity and abundance of the gut microbiota had changed in HUA rats. The Ab-fed HUA rats had significantly lower uric acid content compared to the HUA rats, and gut microbiota from HUA rats increased uric acid content of recipient rats. The genera Vallitalea, Christensenella and Insolitispirillum may associate with HUA. Our findings highlight the association between gut microbiota and HUA, and the potential role played by gut microbiota in HUA. We hope that this finding will promote the isolation and culture of HUA-related bacteria and orient HUA-related studies from being correlational to mechanistic. These steps will therefore make it possible for us to treat HUA using gut microbiota as the target.
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