普鲁士蓝
光热治疗
材料科学
二硫仑
纳米医学
体内
药物输送
螯合作用
纳米颗粒
纳米技术
生物物理学
核化学
冶金
生物化学
化学
物理化学
生物
生物技术
电化学
电极
作者
Wencheng Wu,Luodan Yu,Yinying Pu,Heliang Yao,Yu Chen,Jianlin Shi
标识
DOI:10.1002/adma.202000542
摘要
Abstract In situ toxification of less toxic substance for the generation of effective anticarcinogens at the specific tumor tissue has been a novel paradigm for combating cancer. Significant efforts have been recently dedicated to turning clinical‐approved drugs into anticancer agents in specific tumor microenvironment by chemical reactions. Herein, a hollow mesoporous Prussian blue (HMPB)‐based therapeutic nanoplatform, denoted as DSF@PVP/Cu‐HMPB, is constructed by encapsulating alcohol‐abuse drug disulfiram (DSF) into the copper‐enriched and polyvinylpyrrolidone (PVP)‐decorated HMPB nanoparticles to achieve in situ chemical reaction‐activated and hyperthermia‐amplified chemotherapy of DSF. Upon tumor accumulation of DSF@PVP/Cu‐HMPB, the endogenous mild acidity in tumor condition triggers the biodegradation of the HMPB nanoparticle and the concurrent co‐releases of DSF and Cu 2+ , thus forming cytotoxic bis( N , N ‐diethyl dithiocarbamato)copper(II) complexes (CuL 2 ) via DSF‐Cu 2+ chelating reaction. Moreover, by the intrinsic photothermal‐conversion effect of PVP/Cu‐HMPBs, the anticancer effect of DSF is augmented by the hyperthermia generated upon near‐infrared irradiation, thus inducing remarkable cell apoptosis in vitro and tumor elimination in vivo on both subcutaneous and orthotopic tumor‐bearing models. This strategy of in situ drug transition by chemical chelation reaction and photothermal‐augmentation provides a promising paradigm for designing novel cancer‐therapeutic nanoplatforms.
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