免疫系统
生物
获得性免疫系统
肿瘤微环境
癌症
免疫
长非编码RNA
计算生物学
先天免疫系统
药物发现
免疫抑制
基因
生物信息学
核糖核酸
免疫学
遗传学
作者
Anindya Dutta,Ananya Roy,Subhrangsu Chatterjee
标识
DOI:10.1016/j.drudis.2020.07.026
摘要
The central role of the nonprotein-coding portion of the genome, such as long noncoding (lnc)RNAs is emerging as a hidden player manipulating the immune system in cancer. lncRNAs, in association with their interacting partners, regulate the expression of various immune system genes, which are perturbed during cancer. The tissue-specific expression of lncRNAs and their importance in cellular proliferation, the tumor microenvironment (TME), epithelial-mesenchymal transition (EMT), and modulation of the cells of the innate and adaptive immune system have novel therapeutic implications in establishing lncRNAs as biomarkers and targets to overcome cancer-associated immunosuppression. In this review, we establish and strengthen the link between lncRNAs and cancer immunity.
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