生物
肠道菌群
背景(考古学)
免疫系统
失调
免疫学
免疫球蛋白A
微生物学
免疫球蛋白G
古生物学
作者
Kelsey E. Huus,Charisse Petersen,B. Brett Finlay
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2021-02-10
卷期号:21 (8): 514-525
被引量:94
标识
DOI:10.1038/s41577-021-00506-1
摘要
IgA mediates microbial homeostasis at the intestinal mucosa. Within the gut, IgA acts in a context-dependent manner to both prevent and promote bacterial colonization and to influence bacterial gene expression, thus providing exquisite control of the microbiota. IgA–microbiota interactions are highly diverse across individuals and populations, yet the factors driving this variation remain poorly understood. In this Review, we summarize evidence for the host, bacterial and environmental factors that influence IgA–microbiota interactions. Recent advances have helped to clarify the antigenic specificity and immune selection of intestinal IgA and have highlighted the importance of microbial glycan recognition. Furthermore, emerging evidence suggests that diet and nutrition play an important role in shaping IgA recognition of the microbiota. IgA–microbiota interactions are disrupted during both overnutrition and undernutrition and may be altered dynamically in response to diet, with potential implications for host health. We situate this research in the context of outstanding questions and future directions in order to better understand the fascinating paradigm of IgA–microbiota homeostasis.
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