降冰片烯
自愈水凝胶
药物输送
壳聚糖
肿胀 的
超分子化学
自组装
生物相容性材料
材料科学
自愈
纳米技术
高分子化学
化学
聚合
有机化学
聚合物
分子
生物医学工程
病理
复合材料
替代医学
医学
作者
Sarah L. J. Michel,Alice Kilner,Jean‐Charles Eloi,Sarah E. Rogers,Wuge H. Briscoe,M. Carmen Galán
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2020-07-16
卷期号:3 (8): 5253-5262
被引量:17
标识
DOI:10.1021/acsabm.0c00629
摘要
Access to biocompatible self-assembled gels and microgels is of great interests for a variety of biological applications from tissue engineering to drug delivery. Here, the facile synthesis of supramolecular hydrogels of norbornene (nb)-functionalized chitosan (CS-nb) via UV-triggered self-assembly in the presence of Irgacure 2959 (IRG) is reported. The in vitro stable hydrogels are injectable and showed pH-responsive swelling behavior, while their structure and mechanical properties could be tuned by tailoring the stereochemistry of the norbornene derivative (e.g., endo- or -exo). Interestingly, unlike other nb-type hydrogels, the gels possess nanopores within their structure, which might lead to potential drug delivery applications. A gelation mechanism was proposed based on hydrophobic interactions following the combination of IRG on norbornene, as supported by 1H NMR. This self-assembly mechanism was used to access microgels of size 100-150 nm, which could be further functionalized and showed no significant toxicity to human dermofibroblast cells.
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