Very Low Carbohydrate Diet Effect on Modified Glasgow Prognostic Score: A Randomized Controlled Trial on Stage-IV Colorectal Adenocarcinoma Patients

Background: The stage-IV Colorectal adenocarcinoma patients who cannot be treated with any conventional cancer treatment (surgery, chemotherapy, or radiotherapy) belong to the best supportive care group.Very low carbohydrate diet reduces the glucose supply to the cancer cells through the specific metabolic pathway called the Warburg effect.The cancer cell may "starve" and limit the growth that can be measured by the reduction of the systemic inflammation reaction using modified Glasgow Prognostic Score (mGPS).This study aimed to prove that a very low carbohydrate diet may reduce the systemic inflammation score in adenocarcinoma patients with best supportive care.Methods: Randomized controlled trial of two groups, 12 participants in one groupwere given the diet of very low carbohydrate for three weeks, and the other12 participants in control group were given normal diet.All of the participants were given a diet with the amount of calorie according to their respective needs.We measured serum albumin and C Reactive Protein (mGPS) before and after the intervention.Results: We found statistically significant reduction of modified Glasgow Prognostic Score in the intervention group. Conclusion:The growth of the stage-IV colorectal adenocarcinoma measured by the systemic inflammation indicators was reduced by giving very low carbohydrate diet.