Behavioral and neural correlates of memory suppression in subthreshold depression

功能磁共振成像 心理学 前额叶皮质 神经科学 工作记忆 神经功能成像 神经影像学 海马结构 意识的神经相关物 背外侧前额叶皮质 听力学 认知 医学
作者
Wenjing Yang,Peiduo Liu,Kaixiang Zhuang,Dongtao Wei,Michael C. Anderson,Jiang Qiu
出处
期刊:Psychiatry Research: Neuroimaging [Elsevier BV]
卷期号:297: 111030-111030 被引量:18
标识
DOI:10.1016/j.pscychresns.2020.111030
摘要

Many studies have demonstrated that healthy individuals can intentionally control memory. However, little is known about the behavioral and neural mechanisms of memory control in those with subthreshold depression (SD), a highly prevalent condition associated with severe impairments and a significant social burden. In this study, we used functional magnetic resonance imaging (fMRI) and a generalized form of task-dependent psychophysiological interaction (gPPI) analysis during the think/no-think task to examine the brain mechanism of memory suppression in SD participants. The behavioral results revealed that SD participants were unable to suppress negative memories. Neuroimaging data revealed that the SD group showed greater activation than the healthy control (HC) group in the prefrontal gyrus during memory processing. Moreover, gPPI analysis showed that the SD group had significantly lower right hippocampal functional coupling with the dorsolateral prefrontal cortex during negative memory suppression than the HC group. These results indicated that SD participants recruited more frontal control resources for memory suppression because of executive and prefrontal inhibitory dysfunction. However, the abnormal prefrontal–hippocampal inhibitory pathway resulted in a failure of the memory control process when the stimuli were negative. These findings provide some evidence for understanding why SD individuals have inefficient memory control of negative memories.
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