Catalytic, Enantioselective, CH Functionalization to Form Carbon–Carbon Bonds

This chapter reviews asymmetric CH functionalization reactions in which the newly defined stereochemistry is controlled by the carbon–hydrogen bond cleavage step. Various carbon–carbon bonds are constructed by enantioselective, transition‐metal‐catalyzed, C(sp2)–H and C(sp3)–H activation reactions. The utility of this transformation is demonstrated by its use in the synthesis of biologically active compounds, natural products, and chiral ligand scaffolds for asymmetric catalysis.