化学
光催化
催化作用
硫
芳基
氧化还原
组合化学
溴化物
反应性(心理学)
协同催化
过渡金属
有机化学
有机催化
光化学
盐(化学)
对映选择合成
光催化
烷基
医学
病理
替代医学
作者
Jiakun Li,Junting Chen,Ruocheng Sang,Won Seok Ham,Matthew B. Plutschack,Florian Berger,Sonia Chabbra,Alexander Schnegg,Christophe Génicot,Tobias Ritter
出处
期刊:Nature Chemistry
[Springer Nature]
日期:2019-11-25
卷期号:12 (1): 56-62
被引量:228
标识
DOI:10.1038/s41557-019-0353-3
摘要
Photoredox catalysis, especially in combination with transition metal catalysis, can produce redox states of transition metal catalysts to facilitate challenging bond formations that are not readily accessible in conventional redox catalysis. For arene functionalization, metallophotoredox catalysis has successfully made use of the same leaving groups as those valuable in conventional cross-coupling catalysis, such as bromide. Yet the redox potentials of common photoredox catalysts are not sufficient to reduce most aryl bromides, so synthetically useful aryl radicals are often not directly available. Therefore, the development of a distinct leaving group more appropriately matched in redox potential could enable new reactivity manifolds for metallophotoredox catalysis, especially if arylcopper(III) complexes are accessible, from which the most challenging bond-forming reactions can occur. Here we show the conceptual advantages of aryl thianthrenium salts for metallophotoredox catalysis, and their utility in site-selective late-stage aromatic fluorination.
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