When Can One-level Pedicle Subtraction Osteotomy Obtain Satisfied Outcomes for Severe Thoracolumbar Kyphosis with Global Kyphosis ≥80° in Ankylosing Spondylitis

Study Design. A retrospective study. Objective. The aim of this study was to make a thorough comparison of clinical and radiographic outcomes between ankylosing spondylitis (AS) patients with severe kyphosis who underwent one- or two-level pedicle subtraction osteotomy (PSO) and to determine the indications of one-level PSO. Summary of Background Data. Traditionally, one-level PSO was considered being able to obtain 35° to 40° correction. However, in our practice, one-level PSO might achieve satisfied clinical and radiographic outcomes in AS patients with severe thoracolumbar kyphosis defined as global kyphosis (GK) ≥80°. Methods. Fifty-five AS-related severe thoracolumbar kyphosis patients undergoing one- or two-level PSO from January 2007 to November 2016 were reviewed. The radiographic parameters included thoracic kyphosis (TK), lumbar lordosis (LL), GK, pelvic tilt (PT), sacral slope (SS), pelvic incidence (PI), sagittal vertical axis (SVA), and femoral obliquity angle (FOA). Clinical outcomes were evaluated by Oswestry Disability Index (ODI) and Visual Analogue Scale (VAS). Results. The mean follow-up period was 39.7 ± 20.2 months (range, 24–120 months). Patients who underwent one-level PSO have significantly smaller preoperative GK, SVA, FOA, and larger preoperative LL and SS compared to those who underwent two-level PSO ( P < 0.05). The optimal cutoff points of preoperative radiographic parameters for selecting one-level PSO were: GK <94°, SVA <18.0 cm, and LL <18°. No significant difference was observed between the two groups with regard to preoperative ODI and VAS ( P > 0.05), and the improvement of ODI and VAS ( P > 0.05). Significantly more operative time, blood loss, and fusion levels were found in two-level PSO group ( P < 0.05). Conclusion. One-level PSO might be appropriate for selected severe AS-related kyphosis patients with GK <94°, SVA <18.0 cm, and LL <18°. This finding might be beneficial for surgical decision-making in performing one-level PSO, a relatively less risky procedure, to reconstruct the ideal sagittal alignment in AS patients with severe thoracolumbar kyphosis. Level of Evidence: 2