医学
内科学
焦虑
脑源性神经营养因子
失眠症
医院焦虑抑郁量表
匹兹堡睡眠质量指数
神经营养因子
睡眠质量
麻醉
萧条(经济学)
内分泌学
药理学
精神科
受体
经济
宏观经济学
作者
Yuying Li,Xiaoxing Feng,Hui Ren,Heyu Huang,Yu Wang,Shui Yu
标识
DOI:10.1007/s10517-021-05095-6
摘要
We studied the effects of low-dose ozone therapy on the sleep quality of patients with coronary heart disease (CHD) and insomnia by measuring the levels of brain-derived neurotrophic factor (BDNF) and GABA in blood serum. The 3-month course of low-dose ozone therapy significantly elevated serum BDNF and GABA in CHD patients with insomnia and improved parameters of anxiety, depression, and sleep quality according to Hospital Anxiety and Depression Scale (HADS), Pittsburgh Sleep Quality Index (PSQI), and Self-Rating Scale of Sleep (SRSS). Ozone therapy also significantly (p<0.05) improved the total antioxidant status of the body by elevating catalase activity and reducing malondialdehyde and 8-OHdeoxyguanosine in the saliva. The serum levels of BDNF and GABA negatively and closely correlated with PSQI and HADS scores. Low-dose ozone therapy improved sleep quality and reduced PSQI and HADS scores due to up-regulation of BDNF and GABA.
科研通智能强力驱动
Strongly Powered by AbleSci AI