Research progress of the GJB2 gene deafness-causing mutation and it's characteristics of hearing change

GJB2gene mutation account for 50% autosomal recessive inheritance pattern and nonsyndromic hearing loss.Previous study considered thatGJB2gene deafness-causing always leads to congenital,bilaterally symmetric, non-progressive and profound hearing loss.Research in recent years indicates thatGJB2gene deafness-causing mutation also leads tolate-onset and progressive hearing loss.This paper reviewed the studies onGJB2-associated late-onset and progressive hearing loss and explored the characteristics of hearing change. Key words: GJB2; Gene; Mutation; Hearing