Clinical reliability and validity of the Chinese version of Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery

Objective To evaluate the reliability and validity of the Chinese version of Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB). Methods One hundred and twenty-two inpatients with schizophrenia according to the DSM-IV criteria were measured with the MCCB, and re-measured after 4 weeks. The patients were simultaneously measured with the WCST, RAVEN, Stroop and PANSS to test validity. The controls, including 122 normal community people matched to the patient in gender, age and education, were measured with the MCCB only. Results The test-retest reliability of MCCB composite score was 0.88 (P 0.05). In comparison with normal control, the MCCB scores in schizophrenia were significant lower (P<0.001). Using MCCB scores to classify schizophrenia and normal people by Logistic regression, the correct rate was 84.8%, with sensitivity of 83.6%, and specificity of 86.1%. All the subtests and composite scores of MCCB significantly correlated with the WCST, RAVEN and Strcop scores (P<0.05), which indicated better concurrent validity of MCCB. As to the construct validity, confirmatory factor analysis indicated that seven domains theory model of MCCB was well fired in Chinese version. The tolerability and practicabihty of MCCB were acceptable, and the average performance time was (58±10) minutes. Conclusion The test-retest, inter-raters, consistent and A/B alternate form reliability, concurrent, structure and diagnostic validity of the Chinese version of MCCB meet the requirements of psychometrics, and could be a promising tool for assessing cognitive deficit of schizophrenia patients in China. Key words: Schizophrenia;  Cognition;  Neuropsychological tests;  MCCB;  Reliability;  Validity